Reigns surprised the WWE Universe last Monday night when he revealed that he was first diagnosed with this terrible disease 11 years ago and, after quickly putting him in remission, unfortunately the cancer came back recently.
The Big Dog has taken some time off to fight the disease, but that does not mean it will not make an appearance.
ACE Comic Con He announced that the four-time world champion will be one of the many celebrities who will attend one of his events next year on January 11 in Arizona.
The former Universal Champion will be joined by other WWE megastars, such as five-time women's champion Alexa Bliss, seven-time women's champion Charlotte Flair and former ring announcer Lilian Garcia.
Many other celebrities will also attend the event, such as Marvel star Tom Hiddleston, Krysten Ritter and David Tennant.
Reigns is seen as the next face of the WWE and has shot to the top when he won the Royal Rumble Match 2015, was part of the legendary stable of The Shield, enjoyed four titles of world titles and has defeated legends like The Undertaker, John Cena and Triple H.
The former WWE champion insists that he does not withdraw from the professional fight and, instead, will return better than ever to show that he can overcome any obstacle that life throws at him.
The 33-year-old fighter said: "The reality is that my real name is Joe. [Anoaʻi] and he had been living with leukemia for 11 years … And, unfortunately, he has returned.
"And because the leukemia is back, I can not fulfill my role, I can not be that champion of combat and I will have to abandon the Universal Championship.
"I'm not going to lie, I'll take all the prayers you can send, but I'm not looking for sympathy."
"I'm not looking for you to feel bad about me because I have faith.
"When I was 22, I was diagnosed with this and very quickly I could put it in remission, but I'm not going to lie, that was the most difficult moment of my life."
"I did not have a job, I did not have money, I did not have a home and I had a baby on the way, and football ended with me."
"But you know who gave me the opportunity? The team that gave me the opportunity was the WWE.
"Once the leukemia is over, once again, I'll go home.
"I want to show my family, my friends, my children and my wife that when life throws a curved ball at me, I am the kind of man who will be in that batter's box, I will overwhelm the plate, I will drown and go to swing by the fences every time!